Wolfram Ruf Selected Research

GTP-Binding Proteins (G-Protein)

6/2019	Coagulation Signalling and Metabolic Disorders: Lessons Learned from Animal Models.
5/2014	Role of the protein C receptor in cancer progression.
11/2013	Inflammation, obesity, and thrombosis.
12/2009	Tissue factor and PAR2 signaling in the tumor microenvironment.
9/2008	Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice.
9/2006	Disulfide isomerization switches tissue factor from coagulation to cell signaling.
9/2004	Emerging roles of tissue factor in viral hemorrhagic fever.

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Wolfram Ruf Research Topics

Disease

54	Neoplasms (Cancer) 12/2023 - 09/2002
42	Inflammation (Inflammations) 12/2023 - 04/2003
32	Thrombosis (Thrombus) 12/2023 - 08/2005
12	Breast Neoplasms (Breast Cancer) 01/2023 - 01/2008
12	Neoplasm Metastasis (Metastasis) 01/2020 - 12/2003
11	Sepsis (Septicemia) 01/2020 - 06/2002
10	Hemorrhage 08/2023 - 12/2009
8	Infections 10/2021 - 02/2008
7	Atherosclerosis 11/2020 - 10/2004
6	Venous Thrombosis (Deep-Vein Thrombosis) 04/2024 - 01/2017
6	COVID-19 12/2023 - 01/2021
6	Hypoxia (Hypoxemia) 07/2019 - 10/2006
6	Endotoxemia 11/2015 - 01/2003
5	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/2024 - 10/2008
5	Virus Diseases (Viral Diseases) 12/2023 - 01/2022
4	Hemophilia A (Haemophilia) 08/2023 - 11/2017
4	Obesity 06/2019 - 10/2011
3	Autoimmune Diseases (Autoimmune Disease) 01/2024 - 12/2021
3	Fibrosis (Cirrhosis) 10/2023 - 01/2020
3	Pregnancy Complications 12/2021 - 10/2008
3	Melanoma (Melanoma, Malignant) 10/2021 - 09/2003
3	Atherosclerotic Plaque (Atheroma) 11/2020 - 08/2005
3	Diabetic Nephropathies (Diabetic Nephropathy) 01/2020 - 01/2017
3	Carcinoma (Carcinomatosis) 07/2019 - 01/2014
3	Adenocarcinoma 01/2014 - 09/2008
2	Thrombophilia 12/2023 - 08/2023
2	Venous Thromboembolism 10/2023 - 09/2020
2	Heart Failure 01/2023 - 01/2021
2	Pancreatic Neoplasms (Pancreatic Cancer) 05/2022 - 11/2021
2	Thromboembolism 05/2022 - 11/2021
2	Pneumonia (Pneumonitis) 01/2021 - 02/2008
2	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 08/2011
2	Vascular System Injuries 01/2021 - 10/2006
2	Cardiovascular Diseases (Cardiovascular Disease) 07/2020 - 01/2017
2	Type 2 Diabetes Mellitus (MODY) 01/2020 - 01/2020
2	Hypertension (High Blood Pressure) 01/2020 - 01/2017
2	Ovarian Neoplasms (Ovarian Cancer) 07/2019 - 01/2016
2	Insulin Resistance 06/2019 - 10/2011
2	Necrosis 01/2017 - 09/2015

Drug/Important Bio-Agent (IBA)

74	Thromboplastin (Tissue Factor)IBA 12/2023 - 01/2003
21	Peptide Hydrolases (Proteases)FDA Link 12/2022 - 01/2003
21	Proteinase-Activated ReceptorsIBA 01/2022 - 04/2003
18	Thrombin FDA Link 04/2023 - 04/2003
17	AnticoagulantsIBA 12/2023 - 04/2003
15	Endothelial Protein C ReceptorIBA 12/2023 - 06/2002
14	Proteins (Proteins, Gene)FDA Link 12/2023 - 09/2003
13	Hemostatics (Antihemorrhagics)IBA 08/2023 - 01/2007
12	PAR-2 ReceptorIBA 12/2022 - 09/2006
10	IntegrinsIBA 11/2022 - 07/2004
9	FibrinIBA 08/2023 - 04/2006
9	Protein CIBA 01/2020 - 06/2002
7	Factor VIIa (Activated Factor VII)IBA 03/2024 - 04/2006
7	Complement System Proteins (Complement)IBA 01/2024 - 10/2004
7	GTP-Binding Proteins (G-Protein)IBA 06/2019 - 09/2004
6	Antiphospholipid AntibodiesIBA 01/2024 - 10/2008
6	AntibodiesIBA 10/2023 - 07/2004
6	CytokinesIBA 01/2022 - 01/2007
6	Blood Coagulation Factors (Coagulation Factor)IBA 11/2021 - 10/2006
6	CoagulantsIBA 08/2021 - 06/2002
6	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2010 - 04/2006
5	LipidsIBA 01/2024 - 01/2018
5	fibrin fragment D (D-dimer)IBA 01/2023 - 01/2020
5	Factor VII (Proconvertin)IBA 01/2023 - 10/2006
5	PAR-1 ReceptorIBA 12/2020 - 07/2004
5	Serine Proteases (Serine Protease)IBA 01/2012 - 07/2004
4	lipoprotein-associated coagulation inhibitor (TFPI)IBA 01/2022 - 01/2015
4	LipopolysaccharidesIBA 04/2015 - 06/2007
4	Thrombin Receptors (Thrombin Receptor)IBA 04/2010 - 06/2002
3	bis(monoacylglyceryl)phosphateIBA 12/2023 - 01/2021
3	AntigensIBA 05/2022 - 08/2008
3	ChemokinesIBA 01/2022 - 09/2008
3	Factor X (Stuart Factor)IBA 01/2021 - 01/2019
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 01/2017
3	Angiotensin IIIBA 07/2020 - 01/2017
3	Blocking AntibodiesIBA 01/2016 - 01/2013
3	Peptides (Polypeptides)IBA 01/2012 - 07/2004
2	Phospholipids (Phosphatides)FDA LinkGeneric 12/2023 - 05/2014
2	Histones (Histone)IBA 10/2023 - 01/2020
2	Factor XII (Hageman Factor)IBA 08/2023 - 01/2017
2	Factor XI (Plasma Thromboplastin Antecedent)IBA 08/2023 - 01/2017
2	Heparin (Liquaemin)FDA LinkGeneric 01/2023 - 08/2011
2	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 12/2022 - 04/2008
2	Factor Xa (Coagulation Factor Xa)IBA 10/2021 - 10/2006
2	RivaroxabanIBA 10/2021 - 01/2019
2	Factor Xa InhibitorsIBA 10/2021 - 09/2020
2	Immunoglobulin G (IgG)IBA 01/2021 - 01/2018
2	C-Reactive ProteinIBA 01/2021 - 01/2021
2	Protein Isoforms (Isoforms)IBA 01/2020 - 07/2013
2	ElementsIBA 07/2019 - 12/2009
2	Transcription Factors (Transcription Factor)IBA 07/2019 - 07/2012
2	ChromatinIBA 07/2019 - 10/2006
2	Plasminogen Activators (Plasminogen Activator)IBA 06/2019 - 11/2013
2	Antiviral Agents (Antivirals)IBA 01/2019 - 09/2004
2	recombinant FVIIa (rFVIIa)FDA Link 07/2018 - 11/2017
2	Protein Disulfide-IsomerasesIBA 01/2018 - 05/2012
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2017 - 05/2010

Therapy/Procedure

23	Therapeutics 01/2024 - 04/2003
4	Ligation 04/2024 - 09/2008
4	Drug Therapy (Chemotherapy) 01/2022 - 09/2015
2	Immunotherapy 01/2020 - 01/2019